Sayli Salunkhe rose to fame for her role as Vandana in the show "Baatein Kuch Ankahi Si" opposite Mohit Malik. Despite the show's compelling performance, it ended due to low TRP ratings in March 2024. Sayli then secured the lead role in the series "Pukar."

In a recent interview with Free Press Journal, Sayli addressed rumors about her personal life and criticized the trend of actors sharing intimate details on social media. She believes in maintaining her privacy and focuses on her work and performances rather than updating her relationship status.

Sayli clarified rumors about her friendship with IPL star Ruturaj Gaikwad and expressed concern that such speculation could harm their relationship. She emphasized that her main goal is to be recognized for her work, performances, and dedication to her craft, rather than her personal life. Sayli mentioned that she will only share details about her personal life on social media when she feels comfortable doing so.

Sayli Salunkhe's journey in the industry began with regional language shows before making her Hindi TV debut in "Mehndi Hai Rachne Waali" as Kirti Rao. She went on to appear in "Spy Bahu" and starred opposite Karan V Grover in "Bahut Pyaar Karte Hain" before landing the lead role in "Baatein Kuch Ankahi Si" alongside Mohit Malik.